File-This July 15, 2017, file photo shows Venus Williams of the United States holding the runners-up plate after losing to Spain's Garbine Muguruza in the Women's Singles final match at the Wimbledon Tennis Championships in London.  Andy Roddick was the last American man to win a Grand Slam title, all the way back at the 2003 U.S. Open. The last American woman other than Serena Williams to collect a major trophy? That was Venus Williams, at Wimbledon in 2008. Roddick is retired, inducted into the International Tennis Hall of Fame just last month. Serena Williams is on a sabbatical, expecting her first baby sometime in the next month or so. And Venus Williams? She is still going strong at age 37, adapting to life with an energy-sapping disease well enough to have reached two Grand Slam finals in 2017, the runner-up to her younger sister at the Australian Open in January, then to Garbine Muguruza at Wimbledon last month. (AP Photo/Tim Ireland, File)
File-This July 15, 2017, file photo shows Venus Williams of the United States holding the runners-up plate after losing to Spain's Garbine Muguruza in the Women's Singles final match at the Wimbledon Tennis Championships in London. Andy Roddick was the last American man to win a Grand Slam title, all the way back at the 2003 U.S. Open. The last American woman other than Serena Williams to collect a major trophy? That was Venus Williams, at Wimbledon in 2008. Roddick is retired, inducted into the International Tennis Hall of Fame just last month. Serena Williams is on a sabbatical, expecting her first baby sometime in the next month or so. And Venus Williams? She is still going strong at age 37, adapting to life with an energy-sapping disease well enough to have reached two Grand Slam finals in 2017, the runner-up to her younger sister at the Australian Open in January, then to Garbine Muguruza at Wimbledon last month. (AP Photo/Tim Ireland, File) Credit: ap โ€” Tim Ireland

Andy Roddick was the last American man to win a Grand Slam title, all the way back at the 2003 U.S. Open. The last American woman other than Serena Williams to collect a major trophy? That was Venus Williams, at Wimbledon in 2008.

Roddick is retired; he was inducted into the International Tennis Hall of Fame last month. Serena Williams is on a sabbatical, expecting her first baby sometime in the next month or so. And Venus Williams? She is still going strong at age 37, able to adapt to living with an energy-sapping disease well enough to have reached two Grand Slam finals in 2017. She was runner-up to her younger sister at the Australian Open, then to Garbine Muguruza at Wimbledon.

โ€œMy hat is off to Venus โ€” and I told her this in person years ago โ€” that she figured out what was wrong with her and figured out how to deal with it. And to have that uncertainty of how youโ€™re going to feel every day? But obviously sheโ€™s been managing it really well with her diet and her lifestyle. And the fact that she keeps coming back for more? I donโ€™t think any of us thought that she could win another Slam four or five years ago,โ€ said Martina Navratilova, an 18-time major winner whose last came at age 33.

โ€œGreat to see her still playing,โ€ Navratilova said. โ€œI know when she first came on the tour, she said โ€” both sisters said โ€” โ€˜Thereโ€™s no way Iโ€™m going to play in my late 20s or 30s. No way!โ€™ And here they are. … And how lucky are we?โ€

As the U.S. Open starts Monday, the older Williams sister might be the closest thing to a true title contender among any of the host countryโ€™s men or women. She is, after all, the only player from the United States in either draw to have won a major singles title. Venus Williams owns seven in all, including at Flushing Meadows in 2000 and 2001.

A look at some of the other U.S. players worth keeping tabs on at the yearโ€™s last Grand Slam tournament:

Madison Keys. Best U.S. Open: 4th Round. Ranked: 16th. Age: 22. Born: Illinois. Based: Florida.

Why she has a chance to win the thing: Big serve and forehand can dominate most opponents.

What could stop her: Missed time because of two procedures on her left wrist.

Coco Vandeweghe. Best U.S. Open: 2nd Round. Ranked: 21st. Age: 25. Born: New York. Based: California.

Why she has a chance to make a deep run: Winning second-highest percentage of service points on tour; new coach Pat Cash has helped.

What could stop her: Lost in the first or second round in all eight previous appearances at Flushing Meadows.

Cici Bellis. Best U.S. Open: 3rd Round. Ranked: 36th. Age: 18. Born: California. Based: California.

Why she has a chance to reach the second week: Showed off smooth strokes and fearless attitude last year.

What could stop her: A lack of experience at big events or a bad-luck draw are about it.

John Isner. Best U.S. Open: Quarterfinals. Ranked: 14th. Age: 32. Born: North Carolina. Based: Florida.

Why he has a chance to make a deep run: His serves. Simple as that.

What could stop him: His returns. Simple as that.

Jack Sock. Best U.S. Open: 4th Round. Ranked: 17th. Age: 24. Born: Nebraska. Based: Kansas.

Why he has a chance to make a deep run: Has the classic 1-2 of serve-forehand and capable of feeding off a supportive crowd.

What could stop him: Never reached a Grand Slam quarterfinal and only 3-3 at majors this year.

Sam Querrey. Best U.S. Open: 4th Round. Ranked: 21st. Age: 29. Born: California. Based: California.

Why he has a chance to win the thing: First major semifinal at Wimbledon gives him confidence; his serve can carry him far.

What could stop him: Rarely shows up in New York, with first-round losses the past two years.

Frances Tiafoe. Best U.S. Open: 1st Round, Ranked: 71st, Age: 19, Born: Maryland, Based: Florida.

Why he has a chance to reach the second week: Has an all-around game and a recent hard-court win over top-10 foe Alexander Zverev.

What could stop him: Not a lot of past success on big stages; 2-6 at all major tournaments.