FILE - In this June 23, 2015, file photo, New England Patriots quarterback Tom Brady arrives for his appeal hearing at NFL headquarters in New York. A federal appeals court has ruled, Monday, April 25, 2016,  that New England Patriots Tom Brady must serve a four-game "Deflategate" suspension imposed by the NFL, overturning a lower judge and siding with the league in a battle with the players union. (AP Photo/Mark Lennihan, File)
FILE - In this June 23, 2015, file photo, New England Patriots quarterback Tom Brady arrives for his appeal hearing at NFL headquarters in New York. A federal appeals court has ruled, Monday, April 25, 2016, that New England Patriots Tom Brady must serve a four-game "Deflategate" suspension imposed by the NFL, overturning a lower judge and siding with the league in a battle with the players union. (AP Photo/Mark Lennihan, File) Credit: FILE - In this June 23, 2015, file photo, New England Patriots quarterback Tom Brady arrives for his appeal hearing at NFL headquarters in New York. A federal appeals court has ruled, Monday, April 25, 2016, that New England Patriots Tom Brady must serve a four-game "Deflategate" suspension imposed by the NFL, overturning a lower judge and siding with the league in a battle with the players union. (AP Photo/Mark Lennihan, File)

The never-ending Deflategate saga took another turn Monday when a federal appeals court reinstated the NFL’s four-game suspension of New England Patriots quarterback Tom Brady.

A three-judge panel with the U.S. Court of Appeals for the Second Circuit overturned last year’s ruling by U.S. District Judge Richard M. Berman, who had nullified the league’s suspension of the four-time Super Bowl-winning quarterback.

Brady played all of last season as the Patriots reached the AFC title game before losing at Denver to the Broncos.

“We hold that the Commissioner properly exercised his broad discretion under the collective bargaining agreement and that his procedural rulings were properly grounded in that agreement and did not deprive Brady of fundamental fairness,” the court wrote in its decision.

One of the three judges, Robert A. Katzmann, dissented.

NFL Commissioner Roger Goodell declined to say at his annual state-of-the-league news conference two days before the Super Bowl whether the league would enforce Brady’s suspension during the 2016 season if it prevailed.

The NFL Players Association can appeal the ruling to the full appeals court, but if the ruling stands and the NFL enforces the suspension at the outset of the season, Brady would miss the Patriots’ opener Sept. 11 at Arizona and games at home Sept. 18 against the Miami Dolphins, Sept. 22 against the Houston Texans and Oct. 2 against the Buffalo Bills.

Goodell said at the Super Bowl that the league’s appeal was made in a bid to enforce its rights under the collective bargaining agreement.

“That is not an individual player issue,” Goodell said at the time. “This is about the rights we negotiated in our collective bargaining agreement. We think they are very clear. We think they are important to the league going forward and we disagree with the district judge’s decision. We are appealing that, which is part of the legal process. I am not focused on it right now. I am not going to speculate on what we are going to do. Depending on the outcome, we’ll let the outcome be dictated by the appeals court. When it happens, we’ll deal with it then.”

The NFL issued a written statement Monday that said: “We are pleased the United States Court of Appeals for the Second Circuit ruled today that the Commissioner properly exercised his authority under the collective bargaining agreement to act in cases involving the integrity of the game. That authority has been recognized by many courts and has been expressly incorporated into every collective bargaining agreement between the NFL and NFLPA for the past 40 years.”

The union said it would review its options.

“The NFLPA is disappointed in the decision by the Second Circuit,” a written statement issued by the union said. “We fought Roger Goodell’s suspension of Tom Brady because we know he did not serve as a fair arbitrator and that players’ rights were violated under our collective bargaining agreement.

“Our Union will carefully review the decision, consider all of our options and continue to fight for players’ rights and for the integrity of the game.”

The league suspended Brady for his role in what the NFL concluded was a scheme by the Patriots to use under-inflated footballs that were discovered after the first half of the AFC championship game against the Indianapolis Colts at the conclusion of the 2014 season. Goodell rejected the NFLPA’s appeal of the suspension on Brady’s behalf. Brady’s destruction of his cellphone, leaving it unavailable for league-appointed investigator Ted Wells, also became a significant issue.

The matter ended up before Berman after the league and union filed dueling lawsuits. Berman ruled last September in favor of Brady and the NFLPA, vacating the suspension.

But the NFL appealed, and it was clear to some courtroom observers and legal analysts that the league had a chance to prevail when the appeals-court judges questioned Brady’s attorney, Jeffrey Kessler, more sharply than they did NFL attorney Paul Clement at a hearing in March.

The latest ruling in the Brady-NFL battle continues an upswing of momentum for the league in its handling of player discipline. Berman’s ruling last year came amid a string of successful challenges by the union to disciplinary measures taken by the NFL in cases involving Brady, Ray Rice, Adrian Peterson and Greg Hardy. Against that backdrop, some NFL owners seemed open to the possibility of allowing Goodell’s power in the player-disciplinary process to be reduced.

The league and union negotiated potential changes to the player discipline system and Goodell’s role in it. The NFLPA was seeking independent arbitration for players’ appeals of disciplinary measures imposed by the NFL under the integrity-of-the-game rules, as in Brady’s case, and under the personal conduct policy, as in the Rice, Peterson and Hardy cases. Currently the CBA empowers Goodell to hear and resolve such appeals.

DeMaurice Smith, the executive director of the NFLPA, said at the union’s annual news conference during Super Bowl week he was cautiously optimistic a deal was possible. Subsequently those discussions have broken down, with the NFL’s position strengthened by its recent string of successes, which included an arbitrator ruling in support of the NFL’s tactic of placing players on paid leave while personal conduct cases were investigated. Winning the Brady appeal may further embolden the league, and it is unclear if the player-discipline negotiations will be revived.

The union has said it will not agree to a new collective bargaining agreement, which expires following the 2020 season, without Goodell’s authority in player discipline being addressed.

The Patriots will be without a first-round pick when the NFL draft begins Thursday night as part of their Deflategate penalties.

Brady’s backup, Jimmy Garoppolo, would be in line to open the season as the Patriots’ starting quarterback if Brady is serving his suspension. Garoppolo is the only quarterback besides Brady currently on the Patriots’ roster, which means the team may look to acquire another either during the draft or by signing a veteran free agent.